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Article: Future Diabetes Drugs May Target New Protein Interaction; Proteins Also Link Cellular Aging, Response to Calorie Restriction in Mammals.
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- Article date:
- March 2, 2005
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Byline: Johns Hopkins Medical Institutions
BALTIMORE, March 2 (AScribe Newswire) -- In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the researchers say.
Under normal circumstances, the liver's production of sugar is a back-up plan that enables survival during food shortages; the brain and certain other critical organs ...