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Article: Depression, osteoporosis and inflammatory dysfunction.(Psychoneuroimmunoendocrinology Review and Commentary)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- April 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Depression is a major health problem with 13-20% of the population having depressive symptoms at any given time and [congruent to]5% experiencing major depression. Related pathological processes include ischemia, neoplasia, necrosis, apoptosis, infection, and inflammation. The latter is the most compatible with the waxing and waning course of depression, and could explain the biology of its fluctuating course with severe episodes that can be followed by partial or complete remission. Recent evidence suggests that major depression is associated with dysfunction of inflammatory mediators. Major depression commonly co-occurs with coronary artery disease and decreased bone ...