Article: The oxygen view of osteoporosis: bone homeostasis is but one face of oxygen homeostasis.(Oxygen Homeostasis)

The human anatomy and physiology evolved under the organizing influence of oxygen. (1-4) Accordingly, oxygen not only provides signaling for all developmental, differentiative, and dying processes, it also serves as the principal nutrient for the body. Viewed in that light, bone homeostasis is but one face of oxygen homeostasis. Based on those considerations, I recently put forth the Oxygen Model of osteoporosis that recognizes disturbances of oxygen homeostasis in the bone tissue as the fundamental energetic-molecular events that lead to bone loss clinically designated as osteopenia and osteoporosis. (5)

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In the prevailing model of ...

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