Article: Approach cuts rebleeding in clotted peptic ulcers.(Clinical Rounds)

ORLANDO, FLA. -- A combination of endoscopic and medical treatment of bleeding peptic ulcers with adherent clots results in a significantly lower rebleeding rate than does medical therapy alone, according to findings from a metaanalysis of randomized clinical trials.

Peptic ulcers with adherent clots are problematic because of highly variable rebleeding rates that range from 8% to 36%, Charles J. Kahi, M.D., said at the annual meeting of the American College of Gastroenterology.

In the metaanalysis, patients who received combination therapy had about a 60% lower risk of rebleeding than did those who received medical therapy alone.

During a ...

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