Article: Fecal DNA testing more sensitive than Hemoccult II.(Patient-oriented evidence that matters)

Clinical question Is a fecal DNA test better than the standard Hemoccult II fecal occult-blood test at detecting important colorectal lesions?

Bottom line Fecal DNA testing is more sensitive than the traditional Hemoccult II, although it is also much more expensive and is less sensitive than colonoscopy. (Level of evidence = 1b)

Imperiale TF, Ransohoff DF, Itzkowitz SH, et al; Colorectal Cancer Study Group. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med. 2004;351:2704-2714.

Study Design Cross-sectional

Setting Outpatient (any)

Synopsis Fecal DNA testing looks ...

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