Article: Calcium channel antagonists in pain: blockade of voltage-sensitive calcium channels provides novel agents for pain management.(Second Messenger)

Issue Three FDA-approved agents for pain management work by blocking calcium channels--ziconotide, gabapentin, and pregabalin. How do they work, and for whom do they work?

Actions Learn the mechanism of action of these novel analgesics.

Benefits Understanding their mechanism of action should help the prescriber identify the right time and the right patients for these agents.

Too many patients are suffering pain without adequate relief. Whether it is acute postoperative pain, chronic cancer pain, back pain, or neuropathic pain, undertreated pain severely affects patients' health and quality of life, and has dire social and economic consequences. ...

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