Article: TKT Announces Agreement to be Acquired by Shire for $1.6 Billion.

CAMBRIDGE, Mass., April 21 /PRNewswire-FirstCall/ -- Tranksaryotic Therapies, Inc. today announced that it has signed a definitive agreement with Shire Pharmaceuticals Group plc. (LSE: SHP.L; Nasdaq: SHPGY; TSX: SHQ) under which Shire has agreed to acquire TKT. Shire will pay $37 in cash for each share of TKT common stock, or approximately $1.6 billion, representing a 44% premium to $25.77, which is the last four week average of TKT's closing share price. Closing of this transaction is subject

to, among other things, regulatory clearance and approval of the stockholders of each company. The transaction is expected to close in the third quarter of 2005.

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