Article: Management of locally advanced breast cancer: Evolution and current practice.(Review Article)

Byline: Ashish. Rustogi, Ashwini. Budrukkar, Ketayun. Dinshaw, Rakesh. Jalali

Locally advanced breast cancer (LABC) accounts for a sizeable number (30-60%) of breast cancer cases and is a common clinical scenario in developing countries. The treatment of LABC has evolved from single modality treatment, consisting of radical mutilating surgery or higher doses of radiotherapy in inoperable disease to multimodality management, which along with the above two included systemic therapy. Neoadjuvant chemotherapy (NACT) has made a tremendous impact on the management of LABC. NACT was initiated to institute systemic therapy upfront at the earliest in this group of ...

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