Article: Maxygen and Rentschler Sign Agreement to Manufacture Novel G-CSF.

Maxygen, Inc. and Rentschler Biotechnologie GmbH today announced the signing of an agreement for the scale-up and manufacture of Phase I and Phase II clinical supplies of Maxygen's next-generation granulocyte cell stimulating factor (G-CSF) molecule.

Maxygen has developed a next-generation G-CSF that preclinical studies suggest reduces the duration of neutropenia in comparison to currently marketed products while maintaining the convenience of once-weekly dosing. Preclinical data obtained in established neutropenia models in primate, rat, and mouse suggest that Maxygen's product candidate reduces the duration of neutropenia by clinically relevant shorter periods ...

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