Article: INTEGRILIN(R) (Eptifibatide) Injection When Added to Clopidogrel Provided Superior Platelet Inhibition and Reduced Heart Muscle Death, Based on the Release of Cardiac Necrosis Biomarkers.

-- CLEAR Platelets showed early and sustained platelet inhibition with INTEGRILIN throughout 24 hours --

Millennium Pharmaceuticals, Inc. announced final results from the CLEAR Platelets (Clopidogrel Loading with Eptifibatide to Arrest the Reactivity of Platelets) trial. The study assessed low-to-moderate risk patients and showed that addition of INTEGRILIN, a potent glycoprotein (GP)IIb-IIIa inhibitor, to clopidogrel provided superior platelet inhibition and prevention of heart muscle damage associated with elective coronary stenting versus clopidogrel alone. Heart muscle damage, assessed by measuring cardiac biomarkers, has been previously linked to mortality ...

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