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Article: Profiling phosphorylation of receptor tyrosine kinases using antibody arrays.(APPLICATION NOTE)
- Article from:
- Bioscience Technology
- Article date:
- May 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 Advantage Business Media. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Multicellular organisms have evolved complex intercellular signaling pathways to coordinate the activities of individual cells. Cytokines are extracellular signaling molecules that transduce their signals across cellular membranes by activating transmembrane receptors, such as Receptor Tyrosine Kinases (RTKs). RTKs possess intrinsic tyrosine kinase activity that is activated after ligand binding and receptor dimerization, resulting in phosphorylation of specific tyrosine residues in its own cytoplasmic domain and associated downstream signaling proteins. Reversible phosphorylation of tyrosine residues in RTKs plays a key role in regulating a number ...