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Article: Parental chemical exposures and ras mutations in children.(Headliners: Chemical Exposures and Childhood Leukemia)
- Article from:
- Environmental Health Perspectives
- Article date:
- October 1, 2004
- Author:
CopyrightCOPYRIGHT 2004 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Shu xo, Perentesis JP, Wen w, Buckley JD, Boyle E, Ross JA, Robison LL; Children's Oncology Group. 2004. Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prey 13(7):1230-1235.
A variety of carcinogens have been shown to induce ras mutations in animal and human tumor models, and ras proto-oncogene mutations have been implicated in the development of many malignancies including pancreatic and breast cancers. However, few data exist associating parental exposures and ras mutations in their children. Now a team including NIEHS ...