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Ultralow-dose estradiol and BMD in postmenopausal women.(Tips)

Currently, the recommended treatment for menopausal symptoms is the shortest regimen 1and lowest possible dosage of postmenopausal hormone therapy. The estimated minimum dosage of estrogen necessary to preserve bone mass is based on studies of young women who have undergone oophorectomy. However, these estimates may be too high for postmenopausal women, because even low levels (i.e., less than 20 pg per mL [70 pmol per L]) of endogenous plasma estradiol (Estraderm) can increase bone density and reduce fracture risk in this group. Ettinger and colleagues studied the effect of an ultralow dosage (0.014 mg per day) of transdermal estradiol on bone density and endometrial ...

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