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Article: Temporal variation of chemical composition and relaxant action of the essential oil of Ocimum gratissimum L. (Labiatae) on guinea-pig ileum.(SHORT COMMUNICATION)
- Article from:
- Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
- Article date:
- June 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 Urban & Fischer Verlag. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract
The medicinal plant Ocimum gratissimum L. (Labiatae) is widely encountered in the Northeast of Brasil where it is used to treat digestive problems. Its leaves have an essential oil (EOOG) content whose chemical composition varies according to the time of plant collection. We have compared the effects of the EOOG, collected at 08:00 a.m. (EOO[G.sub.8]) and at 12:00 a.m. (EOO[G.sub.12]), on the relaxation of guinea-pig isolated ileum. Both EOO[G.sub.8] and EOO[G.sub.12] (30-300 [micro]g/ml) reversibly relaxed the spontaneous tonus of the guinea-pig ileum in a concentration-dependent manner, with similar I[C.sub.50] values (49.3 and 23.8 [micro]g/ml, ...