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Article: Low-dose riboflavin may prevent migraines.(Literature Review & Commentary)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- August 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Forty-nine patients with migraines were randomly assigned to receive, in double-blind fashion, daily treatment with 1) a combination of riboflavin 400 mg, magnesium 300 mg, and feverfew 100 mg, or 2) "placebo" (riboflavin 25 mg) for 3 months. The proportion of patients achieving a 50% or greater reduction in migraine frequency (the primary outcome measure) was 42% in the combination group and 44% in the low-dose-riboflavin group (p = 0.87). Both treatments reduced the frequency of migraines by approximately one-third, and decreased the number of migraine days by about one-fourth. In addition, mean headache severity (p = 0.04) and the number of days with tension headache ...