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Article: Tackling High Variability in Gene Expression Studies.
- Article from:
- Genomics and Proteomics
- Article date:
- January 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 Advantage Business Media. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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By Juan Pedro Steibel, Steven P. Suchyta, and Guilherme J. M. Rosa
High variability in gene expression studies often prevents differences from being noticed. To increase power and improve precision of such experiments, special attention should be given to each source of variation functioning in the system.
The advent of microarray technology and other techniques that allow for high-throughput are enhancing the ability to measure gene expression. Each method poses unique limitations and potential for variation. This article reviews different sources of variation and their consequences on statistical power to detect differential expression, and provides ...