Article: New twists on an old theme. (substitution reactions involving aromatic compound formation)

Aromatic substitution underwent a renaissance in the 1980s and today offers a range of new methods which give access to complex or unusual compounds

From the earliest years of aromatic chemistry, when men such as Kekule, Dewar and Baeyer were jockeying for position over the explanation of benzene's structure and reactivity, the wealth of possible aromatic substitution reactions has readily been exploited to make commercially useful products. This continues today and, even after taking account of the tremendous growth and achievements in other branches of organic chemistry (such as aliphatic substitution and stereo-selective synthesis), aromatic (and heterocyclic) ...

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