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Article: Formation of esters, especially phosphate esters, under 'dry' conditions and 'mild' pH.
- Article from:
- Chemistry and Industry
- Article date:
- March 1, 1993
- Author:
CopyrightCOPYRIGHT 1993 Society of Chemical Industry. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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There are several ways of obtaining esters, including biochemically-important phosphate esters. Four main methods are used -- isolation from natural sources; enzymic phosphorylation of a substrate using a specific kinase; chemical synthesis via specialised intermediates and reagents; and direct chemical phosphorylation of a substrate at low pH with phosphoric acid.
In the course of studies concerned with the effects of buffer salts on biological compounds, the authors have observed that direct chemical phosphorylation also occurs at pH values close to neutrality in 'dry' intimate mixtures of inorganic phosphate salts with compounds containing primary and/or secondary ...