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Article: Vitamin D3 more potent than vitamin D2.(comparative analysis)
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- October 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Twenty healthy male volunteers were randomly assigned to receive a single 50,000-IU dose of either vitamin D2 (ergocalciferol) or vitamin D3 (cholecalciferol). Similar increases were seen in the serum concentration of the administered vitamins, indicating equivalent absorption. Both treatments also produced similar initial increases in serum 25-hydroxyvitamin D (250HD) concentrations (the assay measured both 250HD2 and 250HD3) over the first 3 days. However, 250HD levels continued to rise in the vitamin D3 group, peaking at 14 days, whereas 250HD levels fell rapidly in the vitamin D2 group and were not different from baseline at 14 days. The area under the serum ...