Article: Bronchial responsiveness to methacholine in swine confinement building workers.

Recent industrialization has led to raising large numbers of pigs in confinement buildings where ventilation is often inadequate, especially in cold climates where there is a need to reduce heat loss from the buildings. Workers in these buildings are exposed to high concentrations of toxic gases (ammonium and hydrogen sulfide)[1, 2] and organic particles, including animal proteins, grain dusts, bacteria, and fungi.[1, 3-7] The impact of this environmental exposure on respiratory health has been studied extensively.[8] Most reports show an increased prevalence of respiratory symptoms (chronic bronchitis)[5, 9, 10] and some decrease in lung function in these ...

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