Article: Human methadone self-administration and the generalized matching law.

Drugs of abuse function as reinforcers in humans (Griffiths, Bigelow, & Henningfield, 1980; Lamb et al., 1991; Mello & Mendelson, 1980; Mello, Mendelson, & Kuehnle, 1982; Mello, Mendelson, Kuehnle, & Sellers, 1981; Spiga & Roache, 1997). However, to our knowledge, drug reinforcers and concurrent variable interval variable interval (conc VI VI) schedules have been used rarely to investigate quantitatively human drug self-administration. The purpose of this study was to determine whether in humans the generalized matching law (Davison & McCarthy, 1988; Williams, 1988) describes the relation between response allocation and drug intake in humans.

In 1961, Herrnstein ...

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