Article: Sleeping giants: with three launches in the space of six months, nobody's resting easy in the $2.1 billion insomnia market. Sanofi-Aventis is looking to defend Ambien's turf, while Sepracor's Lunesta and Takeda's Rozerem aim to put on share and seek footholds in a suddenly crowded market.

The market for anti-insomnia drugs has all the stuff of a Hollywood thriller: a David-vs.-Goliath story, edge-of-the-seat drama and a cast of thousands.

Sanofi-Aventis hopes to restore some youthful vigor to its blockbuster category-leader Ambien (zolpidem) with a new extended release formula. The franchise's long reign is being challenged by Lunesta (eszopiclone) from Sepracor. Enter Rozerem (ramelteon), another player with a completely new mechanism of action from Takeda Pharmaceuticals North America.

The three new drugs debuted within six months of each other, starting with the April launch of Lunesta, which employed a simultaneous consumer and ...

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