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Blocking the Nerve Receptor EP1 in Mouse Models Reduces Brain Damage Caused by Stroke; New Approach Offers Alternative to COX-2 Inhibiting Drugs.
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Ascribe Higher Education News Service
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December 20, 2005
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Copyright informationCOPYRIGHT 2005 AScribe. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Byline: Johns Hopkins Medical Institutions
BALTIMORE, Dec. 20 (AScribe Newswire) -- Researchers at Johns Hopkins have discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a stroke. The Hopkins study, conducted on mice, is believed to be the first to demonstrate that a protein on the surface of nerve cells called the EP1 receptor is the switch, and that a specific compound, known as ONO-8713, turns it off.
The finding holds promise for the development of effective alternatives to anti-inflammatory drugs called COX inhibitors, which have potentially lethal side effects that limit their use, says Sylvain Dore, Ph.D., ...
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