Article: Systemic vasculitis and prior recent exposure to organic solvents: report of two cases.

PRIOR EXPOSURES to industrial solvents are associated with undifferentiated connective tissue disease, systemic lupus erythematosus, scleroderma, and other conditions. (1-9) Recently, exposure to solvents was shown to be associated with systemic small-vessel vasculitis, in particular Wegener granulomatosis. (10) We report on two patients, one with Takayasu arteritis (TA; a large-vessel vasculitis) and one with microscopic polyangiitis who had prior prolonged occupational exposures to organic solvents.

Case Report 1

A 44-yr-old male electrician, employed as a building control panels operator for 23 mo (8 to 10 hr/d, 6 d/wk), reported headaches and ...

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