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Article: Verdict still uncertain on tiagabine for insomnia.
- Article from:
- Internal Medicine News
- Article date:
- September 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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DENVER -- The anticonvulsant tiagabine (Gabitril) increased slow-wave sleep in a dose-dependent fashion in a 30-center randomized trial involving 232 adults with primary insomnia, James K. Walsh, Ph.D., reported at the annual meeting of the Associated Professional Sleep Societies.
But whether this drug-induced alteration in sleep architecture will translate into clinical utility for the treatment of insomnia remains an unanswered question. Of note, patients given tiagabine didn't report their sleep as being any deeper, more refreshing, or of better quality than patients on placebo. Moreover, tiagabine did not affect total sleep time, latency to persistent sleep, ...