Article: Tonsillopharyngitis Rx.(CLINICAL CAPSULES)

The optimal dose of azithromycin for the treatment of group A streptococcal tonsillopharyngitis in adults is 500 mg/day for 3 days, a metaanalysis of randomized controlled trials suggests.

A total of 19 trials involving 4,626 patients were included in the analysis. The trials compared various 10-day drugs and two different azithromycin doses and treatment durations, Janet R. Casey, M.D., and Michael E. Pichichero, M.D., of the University of Rochester Medical Center (N.Y.), reported.

In the adult trials, a 30-mg/kg dose of azithromycin (over 3 or 5 days) was comparable to the 10-day drugs (odds ratio 0.86). The 5-day Z Pak (500 ...

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