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Article: Council researchers wrestle with SUMO.(BIOMEDICINE)
- Article from:
- Population Briefs
- Article date:
- January 1, 2006
CopyrightCOPYRIGHT 2006 The Population Council, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Little is understood about the molecular mechanisms that regulate sperm production--knowledge that would be key to the development of male contraceptives. Recent research conducted in the laboratory of Patricia L. Morris, a cell biologist and pharmacologist at the Population Council's Center for Biomedical Research, suggests that a protein known as SUMO-1 is involved in numerous aspects of this process. Gaining a greater understanding of SUMO's role in producing sperm, or spermatogenesis, may lead to insights about male infertility and reveal potential targets for male contraception.
SUMOylation
SUMO--which comes in two varieties, SUMO-1 and SUMO-2/3--is ...
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Article: SUMO-Conjugating and SUMO-Deconjugating Enzymes ...
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September 1, 2006 ;
700+ words
... ... by the small ubiquitin-like modifier (SUMO) is a highly dynamic and reversible process. To analyze the substrate specificity of SUMO-conjugating and -deconjugating enzymes ... this system to conjugate the Arabidopsis SUMO isoforms AtSUMO1, 2, and 3 to the model ...
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