Article: A relationship between cigarette smoke oxidants and atherosclerosis.

One of the primary steps in the development of atherosclerosis is the oxidation of low-density lipoprotein (LDL) in the blood by highly reactive molecules known as free radicals.

It has been shown that oxidized LDL is highly atherogenic. Cigarette smoke contains large quantities of free radicals, many of which are known to oxidize LDL.

The multiple layers of antioxidant defenses make it important to characterize the roles and effects of the various components making up that defense. This research sought to determine the effects of cigarette smoke on internally produced antioxidants -- such as dihydrolipoic acid (DHLA) and glutathione -- and externally ...

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