|
|
Article: A relationship between cigarette smoke oxidants and atherosclerosis.
- Article from:
- Nutrition Health Review
- Article date:
- March 22, 1993
- Author:
CopyrightCOPYRIGHT 1993 Vegetus Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
One of the primary steps in the development of atherosclerosis is the oxidation of low-density lipoprotein (LDL) in the blood by highly reactive molecules known as free radicals.
It has been shown that oxidized LDL is highly atherogenic. Cigarette smoke contains large quantities of free radicals, many of which are known to oxidize LDL.
The multiple layers of antioxidant defenses make it important to characterize the roles and effects of the various components making up that defense. This research sought to determine the effects of cigarette smoke on internally produced antioxidants -- such as dihydrolipoic acid (DHLA) and glutathione -- and externally ...