Rozerem.(Hypnotic from Takeda Chemical Industries Ltd for Insomnia)(Brief Article)

Company: Takeda Rx

Pharmacologic class: Hypnotic (melatonin agonist)

Active ingredient: Ramelteon 8mg; tabs.

Indication: Insomnia with difficulty in sleep onset.

Pharmacology: Melatonin is an endogenous hormone that is involved in the maintenance of circadian rhythm. The melatonin receptors M[T.sub.1] and M[T.sub.2] have been identified as playing a role in sleep patterns. Ramelteon is a melatonin receptor agonist with high affinity for melatonin M[T.sub.1] and M[T.sub.2] receptors and selectivity over the M[T.sub.3] receptor. It is theorized that the activity of ramelteon at the M[T.sub.1] and M[T.sub.2] receptors contributes to its ...

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