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Article: Ionic liquid promoted simple and efficient synthesis of [beta]-enamino esters and [beta]-enaminones from 1,3-dicarbonyl compounds--one-pot, three-component reaction for the synthesis of substituted pyridines.
- Article from:
- Canadian Journal of Chemistry
- Article date:
- October 1, 2005
- Author:
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[beta]-Enamino esters and [beta]-enaminones are important precursors for the synthesis of biologically active compounds such as amino acids (1), [gamma]-aminols (1d), peptides (2), and heterocyclic compounds (3).
The most common route for the synthesis of these compounds involves the direct condensation of [beta]-dicarbonyl compounds with amines at reflux in benzene-toluene with azeotropic removal of water (4). Recently, [K.sub.10]clay/ultrasound (5a), silica-supported microwave irradiaton (5b), NaAu[Cl.sub.4] (5c), Bi[(TFA).sub.3] (5d), and Zn(Cl[O.sub.4)].sub.2] x 6[H.sub.2]O (5e) have been used for the condensation of 1,3-dicarbonyl compounds with amines. ...