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Article: Inductive and supressive regulation of TNF production in mouse macrophages with anthrax toxins.(SOUTH CAROLINA JUNIOR ACADEMY OF SCIENCE ABSTRACTS)
- Article from:
- Bulletin of the South Carolina Academy of Science
- Article date:
- January 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 South Carolina Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Anthrax is a potent and often fatal endosporic bacterial infection, making it an ideal biological weapon. Upon entering the body, spores germinate within macrophages and the live bacteria produce multiple toxins. One of these is lethal toxin (made of lethal factor and protective antigen), which has been postulated to cause overproduction of inflammatory cytokines IL-1, IL-6 and TNF-alpha(Tumor Necrosis Factor). In my studies, I have examined the effect of lethal toxins in induction or inhibition of inflammatory cytokines using different doses and varying proportions of lethal toxin subcomponents (protective antigen and lethal factor) using a transformed cell line (RAW) and ...