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Article: Applications of molecular modeling to drug design.(SOUTH CAROLINA ACADEMY OF SCIENCE ABSTRACTS)(Brief article)
- Article from:
- Bulletin of the South Carolina Academy of Science
- Article date:
- January 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 South Carolina Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent increase in computing power and the exponential growth of the knowledge of protein structures has made it possible for organic compounds to tailored to both decrease harmful side effects and increase the potency. Molecular modeling can give insight into the overall stability of bound ligands to protein structures, and therefore, contribute vital ...