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Article: Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin-induced diabetic rats and its active components.
- Article from:
- Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
- Article date:
- January 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Urban & Fischer Verlag. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract
Hypoglycemic effects of the [H.sub.2]O and MeOH extracts of the wood of Taxus yunnanensis were examined in streptozotocin (STZ)-induced diabetic rats. The [H.sub.2]O extract significantly lowered the fasting blood glucose level by 33.7% at a 100 mg/kg dose on intraperitoneal administration. From the active [H.sub.2]O extract of the wood, three lignans, i.e., isotaxiresinol (1), secoisolariciresinol (2) and taxiresinol (3), were isolated as major components. These lignans were further tested for their hypoglycemic effects on the same experimental model. At a dose of 100 mg/kg (i.p.), isotaxiresinol (1) reduced the fasting blood glucose level of diabetic ...