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Article: Design and evaluation of controlled onset extended release multiparticulate systems for chronotherapeutic delivery of ketoprofen.(Research Paper)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- January 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Medknow Publications Pvt. Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Byline: H. Shivakumar, Sarasija. Suresh, B. Desai
An oral controlled onset extended release dosage form intended to approximate the chronobiology of rheumatoid arthritis is proposed for site-specific release to the colon. The multiparticulate system consisting of drug-loaded cellulose acetate cores encapsulated within Eudragit S-100 microcapsules was designed for chronotherapeutic delivery of ketoprofen. Drug-loaded cellulose acetate cores were prepared by emulsion solvent evaporation technique in an oily phase at different drug:polymer ratios (1:1, 2:1 and 4:1). These cores were successfully microencapsulated with Eudragit S-100 following the same technique at ...