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Article: Synthesis and pharmacological screening of 5-methyl-3-[ P -(6'-aryl-2'-thioxo-1',2',5',6'-tetrahydro-pyrimidin-4'-yl)-phenyl]-3 H -2-oxo-D4-1,3,4-oxadiazoles.(Short Communication)
- Article from:
- Indian Journal of Pharmaceutical Sciences
- Article date:
- March 1, 2006
- Author:
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Byline: R. Kamble, B. Sudha
The title compounds were synthesised by using cyclization of a, b-unsaturated ketones and thiourea, in presence of a base. All the newly synthesised compounds have been characterised by elemental analyses, spectral data, and screened for antibacterial, antifungal, anti-inflammatory, and anticonvulsant activities.
The synthesis and biological properties of 3-arylsydnones incorporated with wide variety of potent molecules, have been reported from our laboratory, earlier[1],[2],[3],[4],[5]. During the present work, we have utilised sydnones as synthons for heterocyclic synthesis, as they readily undergo ring transformation to ...