Article: Non-chewable antacid formulations: Effect of different disintegrating agents on their acid Neutralization properties.(Short Communication)

Byline: A. Gadad, P. Dandagi, V. Mastiholimath, M. Patil, V. Rasal, F. Dasankoppa

Aim of the present work is to develop non-chewable antacid tablets using different disintegrating agents viz., microcrystalline cellulose, sodium starch glycolate (Primogel [R]), and cross-linked sodium carboxymethylcellulose (cros-car-mellose sodium [R]). These agents were used alone, and in combinations, both 50% intra-granularly, and 50% extra-granularly. To cover all these variables in the formulations, seven different formulations were designed. Use of different disintegrating agents have shown varying effect on disintegration time and pattern. The disintegration time for ...

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