By Catherine Shaffer

Scientists are using a variety of tools and techniques to determine how the H5N1 influenza virus is mutating.

The spread of influenza A subtype H5N1 beyond its usual reservoirs in Asia has triggered a worldwide flu epidemic--for birds. Since historical flu pandemics are thought to derive from avian viruses, the race is on to learn as much as possible about the molecular determinants of virulence and pathogenicity in the virus and prevent a new pandemic. Scientists trying to track potential mutation pathways for H5N1 have made a number of key findings, including one that calls into question whether a single mutation in H5N1 could lead to a human ...

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