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Article: Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice.(Research article)(includes statistical tables)
- Article from:
- Journal of Clinical Investigation
- Article date:
- May 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 American Society for Clinical Investigation. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Factors that determine the spectrum of target organs involved in autoimmune destruction are poorly understood. Although loss of function of autoimmune regulator (AIRE) in thymic epithelial cells is responsible for autoimmunity, the pathogenic roles of AIRE in regulating target-organ specificity remain elusive. In order to gain insight into this issue, we have established NOD mice, an animal model of type 1 diabetes caused by autoimmune attack against [beta] cell islets, in which Aire has been abrogated. Remarkably, acinar cells rather than [beta] cell islets were the major targets of autoimmune destruction in Aire-deficient NOD mice, and this alteration of intra-pancreatic ...
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... ... Orders to Directly Appear in Hydro-Aire Database Without Human Involvement SEATTLE ... implementation phase with OEM manufacturer Hydro-Aire, Inc., a Crane Co. company (NYSE ... program, which will make the entire Hydro-Aire catalog available through the Avolo web ...
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