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Article: Cytokine-stimulated phosphorylation of GSK-3 is primarily dependent upon PKCs, not PKB.(glycogen synthase kinase-3, protein kinase C, protein kinase B, )
- Article from:
- Biochemistry and Cell Biology
- Article date:
- February 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 NRC Research Press. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Abstract: The regulation of glycogen synthase kinase-3 (GSK-3) by phosphorylation at inhibitory sites has been well documented. In many, but not all, cases, the phosphatidylinositol 3-kinase pathway, and particularly the downstream kinase protein kinase B (PKB) / akt, have been shown to be responsible for GSK-3 phosphorylation. Given that no studies have ever reported cytokine-mediated phosphorylation of GSK-3, we investigated the phosphorylation of this kinase in several hemopoietic cell types in response to either interleukin (IL)-3, IL-4 or granulocyte-macrophage colony stimulating factor (GM-CSF). Each of the cytokines was able to stimulate phosphorylation of the ...
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Article: GSK-3 as a Drug Target in Treating Disorders like ...
M2 Presswire;
September 15, 2006 ;
700+ words
... ... September 2006-Research and Markets: GSK-3 as a Drug Target in Treating Disorders ... and Mood Disorders and the Development of GSK-3 Inhibitors(C)1994-2006 M2 COMMUNICATIONS ... addition of Glycogen Synthase Kinase-3 (GSK-3) and Its Inhibitors: Drug Discovery ...
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