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Article: SLE nephritis associated with certain antibodies.(Clinical Rounds)
- Article from:
- Skin & Allergy News
- Article date:
- December 1, 2005
- Author:
CopyrightCOPYRIGHT 2005 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Patients with systemic lupus erythematosus who develop nephritis are more than five times as likely to have antibodies to lipoprotein lipase in their serum, according to findings from a study led by Morris Reichlin, M.D.
This suggests that the pathogenesis of lupus nephritis may involve cell-surface antigens that activate the complement system and promote vascular damage in the kidney and other organs when they are engaged by antibodies.
In previous studies, other antibodies have been shown to be associated with lupus nephritis, wrote Dr. Reichlin of the University of Oklahoma, Oklahoma City. These include anti-double-stranded DNA (anti-dsDNA), ...