Article: Advancis Pharmaceutical Corp. sees shares soar 46 percent in day.

Byline: Tricia Bishop

Aug. 11--Shares of Advancis Pharmaceutical Corp. soared 46 percent yesterday -- the biggest gain on the Nasdaq -- after the Germantown biotech announced its once-a-day, strep-throat antibiotic had succeeded in a revamped clinical trial. The company plans to seek marketing approval for the drug, which it says could have annual sales of $400 million, by early next year.

Last summer, the treatment failed in two other trials, surprising executives and investors and sending the stock price on its way to an all-time low of 89 cents in late August. The news cost the now 7-year-old company a development partnership and forced executives to ...

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