Article: Mitochondria and cancer.

Introduction

Since the beginning of this century, new avenues in the field of cancer have been emerging, and now, after decades of failure in understanding and curing cancer, the dogma that a functioning cell is subordinate only to its DNA is in decline. Biologists are no longer convinced that the development of cancer is simply a result of a cell's genes and of the DNA that carries the cell's inheritable instructions, but does not necessarily control those instructions.

Of the new theories on cellular DNA mutation and cancer, one is firmly based on the notion that mitochondria can indeed regulate genomic activity. In 1999, I described some of my work ...

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