Article: Biological monitoring of occupational exposure to enflurane (ethrane) in operating room personnel.

THE BIOLOGICAL CHANGES and the adverse effects produced by the main inhalation anesthetics have been studied mostly in experimental animals; human studies have mainly dealt with patients receiving presurgical anesthesia. Studies are lacking on subjects chronically exposed to these substances for occupational reasons.[1] Enflurane (ethrane; CAS 13838-16-9), alone or in combination with nitrous oxide ([N.sub.2]O), is used widely as general inhalation anesthetic. Occupationally exposed groups include anesthesiologists, other physicians (e.g., surgeons), and operating room nurses.

Enflurane has structural analogies with bis-chloromethyl ether, which is very ...

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