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Article: Messed Up Just Right Conditional Degron Opens Up Reversible Protein Knockouts By Anette Breindl Science Editor.
- Article from:
- BIOWORLD Today
- Article date:
- September 27, 2006
CopyrightCOPYRIGHT 2006 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Silencing genes at either the DNA or RNA level is among the most popular tricks in the cell biologist's toolbox. And in the Sept. 8, 2006, issue of Cell, researchers from Stanford University completed the set, reporting on, as the title of their paper states, "A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules." Senior author Thomas Wandless listed several advantages that the new system has over silencing at the DNA or RNA level. For one thing, the degron system is an order of magnitude faster: It works in two to four hours, while with DNA or RNA interference it typically takes 24 to 36 hours until the ...
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