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Article: Organometallic chemistry.
- Article from:
- Chemistry and Industry
- Article date:
- April 18, 1994
- Author:
CopyrightCOPYRIGHT 1994 Society of Chemical Industry. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Reactions of organothallium reagents have never been popular for synthetic chemistry, because of the toxicity of these reagents. Marko and Leung argue that the toxicity of thallium is commonly exaggerated, and their group has begun to investigate reactions of organothallium ate-complexes in detail (J. Am. Chem. Soc., 1994, 116, 371). They have found that a reagent formed from [Me.sub.3]Tl and MeLi, for instance, adds to conjugated ketones much faster than non-conjugated ones (for example, Reaction 1). The reaction is proposed to proceed via single electron transfer (Scheme 1), hence the enhanced reactivity of conjugated ketones correlates with their lower reduction ...