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Stomach acid interacts with thyroid hormone treatment.(Literature Review & Commentary)(Brief article)

Two hundred forty-eight patients with multinodular goiter who were receiving treatment with thyroxine were studied. Fifty-three of the

patients also had Helicobacter pylori-related gastritis, and 60 had atrophic gastritis (31 with evidence of H. pylori infection and 29 without such evidence). The daily requirement of thyroxine to maintain a low TSH level (0.05-0.20 mU/L) was 22-34% higher in patients with H. pylori-related gastritis, atrophic gastritis, or both conditions than in patients without those conditions. In prospective studies, the development of H. pylori infection in 11 patients treated with thyroxine led to an increase in the TSH level (p = 0.002), an effect that ...

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