Article: Use of the chi-square test to determine significance of cumulative antibiogram data.

Abstract: An important function of a hospital's Infectious Disease and Pharmacy programs is to review and compare the most recent antibiogram with that of the previous year to determine if significant changes in antibiotic susceptibility results are noted and to communicate this information and its consequences to the medical staff. However, there are currently no formal analytical (decision-making) models in use to determine if the rate of resistance to an antibiotic from one year to the next has significantly changed more or less than one would expect due to sampling error and test reliability. The purpose of this article, therefore, is to demonstrate the utility of ...

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