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Article: Histone deacetylase enzymes as potential drug targets in cancer and parasitic diseases.
- Article from:
- Journal of Biomedicine and Biotechnology
- Article date:
- January 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Hindawi Publishing Corp. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The elucidation of the mechanisms of transcriptional activation and repression in eukaryotic cells has shed light on the important role of acetylation-deacetylation of histones mediated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. Another group belonging to the large family of sirtuins (silent information regulators (SIRs)) has an (nicotinamide adenine dinucleotide) NA[D.sup.+]-dependent HDAC activity. Several inhibitors of HDACs (HDIs) have been shown to exert antitumor effects. Interestingly, some of the HDIs exerted a broad spectrum of antiprotozoal activity. The purpose of this review is to analyze some of the current data ...
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Article: Repression of Gene Expression by HD2-type Histone ...
In Vitro Cellular & Developmental Biology;
April 1, 2004 ;
653 words
... ... to one class of histone deacetylascs that is plant specific and shows no sequence homology to other classes of histone deacetylases. We demonstrated that Arabidopsis HD2-type proteins, AIHD2A, AtHD2B and AIHD2C, can repress gene expression ...
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