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Article: The creatine kinase/creatine connection to alzheimer's disease: CK inactivation, APP-CK complexes, and focal creatine deposits.(amyloid precursor protein)
- Article from:
- Journal of Biomedicine and Biotechnology
- Article date:
- January 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Hindawi Publishing Corp. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Cytosolic brain-type creatine kinase (BB-CK), which is coexpressed with ubiquitous mitochondrial uMtCK, is significantly inactivated by oxidation in Alzheimer's disease (AD) patients. Since CK has been shown to play a fundamental role in cellular energetics of the brain, any disturbance of this enzyme may exasperate the AD disease process. Mutations in amyloid precursor protein (APP) are associated with early onset AD and result in abnormal processing of APP, and accumulation of A[beta] peptide, the main constituent of amyloid plaques in AD brain. Recent data on a direct interaction between APP and the precursor of uMtCK support an emerging relationship between AD, ...
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