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Article: Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein.(Research Communication)(Clinical report)
- Article from:
- Mediators of Inflammation
- Article date:
- January 1, 2006
- Author:
CopyrightCOPYRIGHT 2006 Hindawi Publishing Corp. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H, receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interaction of olopatadine with S100A12 inhibits the proinflammatory effects of S100A12. Pretreatment of olopatadine with S100A12 reduced migration of THP-1, a monocyte cell line, induced by S100A12 alone, but did not affect recombinant human regulated upon activation, normal T cell expressed ...
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